Varicella-Zoster Virus-Genetics, Molecular Evolution and RecombinationArticle Published on 2023-01-012023-05-31 Journal: Current Topics in Microbiology and Immunology [Category] 두창, 수두, 홍역, [키워드] Expression kinetics Genome molecular evolution Phylogeny Recombination Transcriptome Varicella-zoster virus. [DOI] 10.1007/82_2021_238 PMC 바로가기
Transcriptomic analysis of the innate immune signatures of a SARS-CoV-2 protein subunit vaccine ZF2001 and an mRNA vaccine RRVSARS-CoV-2 단백질 소단위 백신 ZF2001 및 mRNA 백신 RRV의 타고난 면역 특징의 전사체 분석Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] Activation Analysis Anti-viral antibody approach binding CD74 Cell comparable COVID-19 cytokine Cytokines early response elicited expression level expression of gene framework Gene Expression Genes immune response immune responses immunization innate immune innate immune response Innate immunity involved mapped MHC class mRNA mRNA vaccine neutralization Neutralization antibody Pattern recognition pattern recognition receptor Pattern recognition receptors post vaccination Protein subunit protein subunit vaccine PRRs RNA degradation robust SARS-CoV-2 SARS-CoV-2 protein subunit Subunit vaccine Tap1 titre titres Transcription transcriptional Transcriptome transcriptome sequencing Transcriptome sequencing. transcriptomic transduction Vaccine ZF2001 [DOI] 10.1080/22221751.2022.2059404 PMC 바로가기 [Article Type] Article
Comparative miRNA transcriptomics of macaques and mice reveals MYOC is an inhibitor for Cryptococcus neoformans invasion into the brain원숭이와 생쥐의 비교 miRNA 전사체는 MYOC가 뇌로의 크립토코커스 네오포르만스 침입에 대한 억제제임을 보여줍니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] 유전자 메커니즘, [키워드] AIDS Brain brain dissemination brains C. neoforman C. neoformans caused Central nervous system centric clinical samples clinically CNS Comparative Cryptococcal meningoencephalitis cryptococcosis Cryptococcus neoforman Cryptococcus neoformans cytoskeleton dissemination enhancer facilitate fungal Fungal infection help HIV/AIDS HIV/AIDS patient HIV/AIDS patients host-pathogen interactions hosts human pathogen Immune cell immune cells individuals Infection inhibitor inhibitors Invasion macaque Macrophage mechanism meningoencephalitis mice miRNA miRNA transcriptome. MYOC myocilin Pathogenic microorganisms pathway Patient patients with COVID-19 performed Prevalence regulated response reveal Transcriptome transcriptomics Trojan horse [DOI] 10.1080/22221751.2022.2081619 PMC 바로가기 [Article Type] Article
Lineage abundance estimation for SARS-CoV-2 in wastewater using transcriptome quantification techniquesArticle Published on 2022-11-082022-11-16 Journal: Genome Biology [Category] SARS, 변종, 유전자 메커니즘, [키워드] Algorithm can be used clinical samples effort high variability Lineage MONITOR mutant pandemic Prevalence quantification SARS-CoV-2 SARS-CoV-2 mutant SARS-CoV-2 RNA Sequencing Spread Surveillance Transcriptome [DOI] 10.1186/s13059-022-02805-9 PMC 바로가기
The Peripheral Immune Landscape in a Patient with Myocarditis after the Administration of BNT162b2 mRNA VaccineArticle Published on 2022-10-312022-11-15 Journal: Molecules and cells [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome analysis approved BNT162b2 BNT162b2 mRNA vaccination causes cell clusters change changes in complications coronavirus Differentially expressed genes global public health help IL7R immune increased expression increased risk landscape Messenger RNA monocyte mononuclear cell mRNA myocarditis of BNT162b2 pandemic Pathogenesis Patient PBMC PBMCs peripheral Peripheral blood peripheral blood mononucleear cells reported Research SARS-CoV-2 Sequencing severe acute respiratory syndrome coronavirus 2 single-cell Single-cell RNA sequencing single-cell RNA sequencing. T cell receptor Transcriptome transcriptomic profile vaccinated individual vaccination Vaccine [DOI] 10.14348/molcells.2022.0031 PMC 바로가기
Immunological and Pathological Peculiarity of Severe Acute Respiratory Syndrome Coronavirus 2 Beta VariantArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] Activation acute respiratory syndrome analysis Beta Beta variant blockade cascade cause CCL2 Characteristics Comparative analysis coronavirus coronavirus 2 COVID-19 COVID-19 pandemic CXCR2 cytokine cytokine release death Disease progression early stage evidenced IL-1β immunological induce Infection Inflammatory cytokine investigated K18-hACE2 late stage Lung pathology mice molecular mechanism Mortality neutrophil recruitment outbreak pathological pathological condition pathology phenotype presymptomatic provide reduced respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 variant secreted cytokine Strains the SARS-CoV-2 Transcriptome transcriptomes Transmissibility Treatment variant Variant. viral infection weight loss [DOI] 10.1128/spectrum.02371-22 PMC 바로가기
Humoral immunity and transcriptome differences of COVID-19 inactivated vacciane and protein subunit vaccine as third booster dose in humanArticle Published on 2022-10-212022-11-16 Journal: Frontiers in Immunology [Category] 변종, 유전자 메커니즘, [키워드] analyzed antibody approach booster booster dose caused correlation COVID-19 differentially expressed gene dose effective Effectiveness Efficacy Factor Health help Heterologous homologous humoral humoral immune response Humoral immunity immune Immune escape immune response Immunity immunization inactivated Inactivated vaccine indicated innate immune function innate immune pathways participant Perspective Prevalence protein subunit vaccine provided significantly Support System third booster vaccine transcriptional response Transcriptome transcriptome analysis transcriptomic analysis vaccination Vaccine variants of concern variants of concern. VOCs with COVID-19 [DOI] 10.3389/fimmu.2022.1027180 PMC 바로가기
Reconstructed Genome-Scale Metabolic Model Characterizes Adaptive Metabolic Flux Changes in Peripheral Blood Mononuclear Cells in Severe COVID-19 PatientsArticle Published on 2022-10-172022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome adaptive aerobic Analysis anti-inflammatory effect antiviral drugs biogenesis caused change changes in Coronavirus disease 2019 Coronavirus-2 COVID-19 differentially expressed enzyme FASN fatty flux Glycolysis Health Immune cell Inflammation Inflammatory lipids mechanism metabolic metabolic model metabolism metabolism-directed therapy. metabolites Model mononuclear cell nucleotide oxidative phosphorylation pathogenic PBMC PBMCs peripheral Peripheral blood potential therapeutic targets provide reaction reconstructed Regulation responsible retinol SARS-CoV-2 severe COVID-19 patients SLC2A3 therapy Transcriptome Treatment Vitamin [DOI] 10.3390/ijms232012400 PMC 바로가기
TIMELESS is a key gene mediating thrombogenesis in COVID-19 and antiphospholipid syndromeArticle Published on 2022-10-142022-11-15 Journal: Scientific Reports [Category] 유전자 메커니즘, 진단, [키워드] Analysis analysis antibody autoantibody autophagy gene Bioinformatics analysis Cell circadian clock Coagulation contribute COVID-19 COVID-19 patient COVID-19 patients Critically ill cytoHubba Cytoscape software dataset Differentially expressed genes evaluated expression Genes Genetic GSK3B identify Immune-mediated Immunotherapy increased risk Interference investigated Kyoto mechanism Mild Modification mononuclear cell ontology term pathway Patient patients protein-protein interaction Proteins regulate severe COVID-19 severe COVID-19 patient severe COVID-19 patients severity suggested Symptom syndrome therapeutic potential thrombosis Transcriptome were used with COVID-19 [DOI] 10.1038/s41598-022-21694-3 PMC 바로가기
Analysis of transcriptomic responses to SARS-CoV-2 reveals plausible defective pathways responsible for increased susceptibility to infection and complications and helps to develop fast-track repositioning of drugs against COVID-19Research article Published on 2022-10-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 유전자 메커니즘, 진단, 치료제, [키워드] acute respiratory distress Affect Algorithm Analysis antiviral therapy Brain causes clinical study Col1a1 collagen Comorbidities Complication complications component Control coronavirus COVID-19 COVID-19 patients develop diagnostic drug drug repositioning FDA approved drug Genetic help immune system independent Infection Inflammation Inflammatory response Influenza involved kidneys Lungs machine learning methodology offer other organ pathway Pathways Patient performed principal Regulation response responsible Result reveal RSV SARS-CoV-2 SARS-COV-2 infection severity Side effect Side effects Small scale genetic signature susceptibility syndrome the disease the interferon Transcriptome transcriptomic transcriptomic analysis transcriptomic data virus replication [DOI] 10.1016/j.compbiomed.2022.106029 [Article Type] Research article